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![]() Shakespeare’s English history plays absorb this reading of past events from Holinshed, their principal source, but they also subject its assumption to skeptical questioning. (See “ The line of Edward III.” ) In the narrative constructed by these chroniclers, the murderous confusions of fifteenth-century history served only to demonstrate the providential scheme by which God revenged the murder of a rightful king (Richard II ) and purged the nation of its crimes before placing the Tudors on the throne and restoring the English people to their status as God’s elect. Reaching its bloody climax in the reign of the Yorkist Richard III, the national ordeal was at last brought to an end by Richarďs overthrow at the hands of the first Tudor king, Henry VII, grandfather of Elizabeth I. They described a long-drawn-out dynastic crisis that followed the deposition and murder of Richard II-a crisis that, after the brief heroic respite achieved by the Lancastrian Henry V, erupted in civil war (the Wars of the Roses ) under his son, Henry VI. This century-long period of turmoil had already received considerable attention from such chroniclers as Edward Halle and Raphael Holinshed, the creators of what is sometimes called the “Tudor myth” of English history. ![]() The Life of Henry V is a “history play” in more senses than one: it is a play about how history is made, and also how it is remade it is a representation of past events while being at the same time an examination of the uses of the past and it is a play whose own reconstruction of history consciously intervened in the historical process.Īs the text itself reminds us, Henry V was the latest of a series of English history plays in which Shakespeare had dramatized the fifteenth-century conflict between the royal families of York and Lancaster. “It is not the literal past, the ‘facts’ of history, that shape us, but images of the past embodied in language.” ![]() The Top 10 Fastest Hypersonic Aircraft Ever Recorded (Manned & Unmanned).Other private jets that can fly in the 600+ miles-per-hour range include the Gulfstream G-500, the Bombardier Global 5000, and the Dassault Falcon 7X. 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Click the Link to Download basICColor display 5.6.2 build 76.86 Multilangual (Win/Mac) Crack Patch. basiccolor display basiccolor display 5 Download BasICColor Display 3.0.3 (BasICColor. ![]() That’s because Burt was the subject of a 2016 warning letter from the Food and Drug Administration, which oversees clinical trials. “When you use it in the right group of patients with MS, you get these really gratifying results.”īut some researchers are also questioning the integrity of the study’s findings. “I do think it’s going to change the natural history of MS,” said Northwestern University stem cell researcher Richard Burt, the study’s lead author and Loy’s doctor. The small trial appears to provide more evidence that chemo and a stem cell transplant can help some people with MS. The rest saw their quality of life and disability improve. ![]() But for the 55 (including Loy) who received the chemo and stem cell transplant, only three got worse. The results of the trial appeared on January 15 in the journal JAMA : Among the 55 patients in the control group who took medication, 34 saw their disease worsen. Loy got it as part of the first randomized trial comparing the outcomes of patients with what’s called “relapsing remitting” MS who received the treatment to patients who took standard MS medications. The treatment is an experimental chemotherapy and hematopoietic stem cell transplant. (Heads up: You might be asked to sign in to Google first.) Become a member of the Vox Video Lab on YouTube today. “It sounds so dramatic, but gave me my life back,” she said. Her only lingering symptom is some mild nerve pain from time to time. She runs half-marathons and plays soccer with her son, who is 10. Nearly a dozen years on, Loy is now back to working full time as a teacher in the radiology program at the University of Alaska. It was around then that she decided to travel from her home in Anchorage, Alaska, to Chicago to inquire about a new treatment she’d heard about at a Seattle hospital. After she gave birth to a son a year later, in 2008, the symptoms worsened. Her hands and legs felt numb all the time, her bladder always felt full, and she had to rely on a cane to walk for more than 10 minutes. The story has been heavily updated with information about the letter and the perspectives of bioethicists and health law experts.īy the time Amanda Loy turned 28, her multiple sclerosis had progressed to the point that she could no longer work full time. "Hastening the return of the body’s white blood cells can reduce the possibility of serious or overwhelming infection associated with stem cell transplantation.Editor’s note 1/23/19: After this piece was published on January 15, a reader informed us that the lead author in the study described below had received a warning letter from the Food and Drug Administration in 2016. "Today's approval is an important advance in cell therapy treatment in patients with blood cancers," Peter Marks, M.D., Ph.D., director of the FDA Center for Biologics Evaluation and Research, said in a statement. ![]() Within 100 days of transplantation, bacterial or fungal infections were seen in 39 percent of those receiving Omisirge versus 60 percent who received umbilical cord blood. Among patients randomly assigned to Omisirge, 87 percent achieved neutrophil recovery with a median of 12 days following treatment versus 83 percent of participants randomly assigned to receive umbilical cord blood transplantation (median 22 days for neutrophil recovery). The approval was based on data from a randomized, multicenter study comparing transplantation of Omisirge to transplantation of umbilical cord blood, in 125 patients with blood cancer (ages, 12 and 65 years). The treatment is composed of human donor stem cells from umbilical cord blood that are processed and cultured with nicotinamide. Omisirge is administered as a single, patient-specific intravenous dose for blood cancer patients ≥12 years to hasten recovery of neutrophils. Food and Drug Administration approved Omisirge (omidubicel-onlv), a substantially modified allogeneic cord blood-based cell therapy, to cut the risk of infection in patients with blood cancer following a myeloablative treatment, such as radiation or chemotherapy. FDA Approves Cord Blood Stem Cell Product, Omisirge, for Blood Cancer Patients ![]() A “mine” themed level, for instance, introduces area-of-effect explosives. Even in the first few sections, where all personality has been sterilised, there’s still a sense of this being the “tutorial” world. Each chapter draws in some new ideas, which match up well with the level’s themes. There is some variety in how you messily exit this plane of existence. That’s an average death every 7 seconds.” “…I died 6287 times, over a 13-hour campaign. You can jump, you can dash, but above all else, you can just get physically obliterated so so many times. This is a precision platformer with some cool ideas. If you watch the trailer above, truly you will understand a lot of what the game is working with. Sunblaze, in many ways, is a very straightforward title. It’s definitely full of controller clutching tension, though it lacks the comprehensiveness of Celeste’s gameplay mods. I personally love a good marriage of story and gameplay, something Celeste excels at, whereas Sunblaze tilts more towards the challenging gameplay side of the spectrum. It is a somewhat balanced comparison, with Sunblaze falling a little shy of the lofty heights reached by the 2018 precision platformer. Sunblaze is inspired by Celeste, and as a fan, I saw the connection between the two instantly. If you’re not into difficult games, this might not be the title for you. However, I’d be lying if I said I didn’t have a rough time playing through this one. Sunblaze is a handcrafted, precision platformer that boasts an ability to “keep you dying for hours and hours.” It’s a good game and one I happily recommend. ![]() "The river, reflecting the clear blue of the sky, glistened and sparkled as it flowed noiselessly on." Idyllic: This is a calm and peaceful feeling, and the mood can sometimes be created by describing a natural setting, like in the countryside, as in this example from Charles Dickens' Pickwick Papers: ![]() Darcy, "I could easily forgive his pride if he had not mortified me." ![]() Jane Austin in Pride and Prejudice uses humor and absurd characters to take a comical look at love, reputation, and class.įor example, Elizabeth says the following humorous phrase about Mr. This mood can be used to alleviate a somber or dangerous situation or to ridicule or satirize a situation. Characters will do and say odd or funny things. Humorous: This mood is silly and sometimes ridiculous. Travers in Mary Poppins creates a cheerful mood throughout the story by using silly words, such as "supercalifragilisticexpialidocious," taking the reader on wild adventures with the children and filling the pages of the book with scenes that make you laugh out loud. A cheerful mood fills you with joy and happiness. Some common moods found in literature include:Ĭheerful: This light-hearted, happy mood is shown with descriptions of laughter, upbeat song, delicious smells, and bright colors. The atmosphere takes the reader to where the story is happening and lets them experience it much like the characters. Atmosphere is the feeling created by mood and tone. The author's attitude or approach to a character or situation is the tone of a story and the tone sets the mood of the story. This feeling is the result of both the tone and atmosphere of the story. In literature, mood is the feeling created in the reader. Words such as frightened, panicked and depressed are commonly used to describe people's moods during this time. People lost their jobs, went hungry and experienced a wide range of emotions. For example, during the Great Depression, the mood in the USA can be thought of as somber. Use words that describe how people felt during the time and reflect on how they lived their lives. When referring to a period of time or specific era, moods can be used to set the scene. The mood set for this beach is calm and peaceful. For example, if writing about a beach use words such as salty sea air, gentle breeze, soft sand, lapping waves or warm sun rays. When describing a place, you will want to add plenty of detail and use vivid words. If a group of students gets to go on a fun field trip for the day instead of sitting in the classroom, the mood can be described as excited or elated.ĭescriptive writing can be used to set the mood of a place. For example, if something unfair happens in the workplace and a group of employees lost their jobs, this group's mood can be described as frustrated and enraged. When describing how a group is feeling, a collective mood is often used. While moods are commonly used to describe how an individual person feels at a given time, they also can be used to describe the atmosphere of groups of people, places, and eras or time periods. ![]() Regardless if you are cutting across the back roads on a C元50 or CL450 Scrambler, buzzing through the city on your CB360, CB350 or CB175 or even on that long haul road trip on your CB550 or CB750, having a handful of Posi-taps and Posi-locks in your tool kit will be a handy solution to any unforeseen wiring gremlins. ![]() Sold in packs of 10, they work on any 14-16 gauge wire (factory Honda wiring harnesses are mostly 16 gauge). No special tools are required to install, the Posi-Taps are re-useable, they stay tightly in place and if removed, the original wire is left in tact with minimal distortion (just a little hole that can be taped or touched up with silicone). Posi-Taps provide a quick, easy and semi-permanent way to splice a new wire into an existing harness. These may be the best wire taps ever made and they are the best ones we have ever used. We recently stumbled across Posi-Tap wire connectors when looking for an easy to use connector to include with our a Shockwave ignition system. The T-tap or clam shell type wire tap connectors have been on the market for years, but are real junk as they always seems to wiggle loose and are permanent once installed. However, we know that almost never happens and that we want a quick and simple solution. ![]() The best way to make such a mod is to strip, splice and solder the new wires to the existing ones. Why You Need This: Every now and then, the situation arises that an electrical device needs to be connected or "tapped" into an existing wiring harness. Part: Posi-Tap Wire Splice Electrical Connectors Whereas this annotation reveals that Mildor means “land of wine”, Dorwinion in fact means “land of Gwinion ” ( Parma Eldalamberon XVII, p. Both “Mildor” and “Dorwinion” are Sindarin names. Google is letting users go to Middle-earth and back again with a new Chrome experience based on the upcoming sequel to 'The Hobbit.' As anyone who spent their childhood poring. “MILDOR ” scribbled out.Further examination of the map has also revealed that “Dorwinion” was initially labelled “MILDOR ” by Tolkien before being scribbled out and re-labelled “Dorwinion”. Susan Theobald at Blackwell’s Rare Books has now completed the painstaking task of transcribing the annotations by both Baynes and Tolkien, and has kindly shared the end-product with the Tolkien Society. A catalogue can be viewed online, and hard-copy is available on request. In the late 1960s Baynes collaborated with Tolkien to produce a poster-map - known as “ A Map of Middle-earth” and first published in 1970 - based on the map of Middle-earth found in most copies of The Lord of the Rings.īlackwell’s Rare Books are currently selling a large number of items from Pauline Baynes’s collection. Archival Geography include all places on the map found within the game that are of interest, as the boundaries and borders known as Locations, Interiors, or as. If Sam and Frodo had had this Google Map of Middle Earth, their journey would likely have been a lot easier than the one in the Lord of the Rings. Tolkien had been re-discovered in a copy of The Lord of the Rings owned by the late Pauline Baynes. Created by Mark Crosby, found via reddit. Late last month we reported that a map of Middle-earth featuring annotations by J.R.R. ![]() The term is equivalent to the Miðgarðr of Norse mythology and Middangeard in Old English works, including Beowulf. ![]() The map of Middle-earth annotated by illustrator Pauline Baynes and Tolkien himself has now been transcribed by Blackwell’s Rare Books. Middle-earth is the setting of much of the English writer J. Posted by Daniel Helen at 19:17 on 10 November 2015 ![]() Aircall doesn’t store passwords or customers’ credit card information.Īircall also operates a vendor management program that is designed to protect sensitive information and complies with all relevant laws. The company follows recommendations from security frameworks including SOC2 and PCI/DSS. All customer data is encrypted, protected, and stored in data centers. Aircall VoIP: interface and in useĪircall takes security seriously. 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